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An imaginary illness. He has got the humdurgeon, the thickest part of his thigh is nearest his a-se; i.e. nothing ails him except low spirits.
Definition taken from The 1811 Dictionary of the Vulgar Tongue, originally by Francis Grose.
Hum Drum * HumbugsNathan Bailey's 1736 Dictionary of canting and thieving slang
John S. Farmer's collection of canting songs and slang rhymes
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Francis Grose was independently wealthy, having inherited money from his father, a jeweller. Finding himself overspending, he published a number of books; his Provincial Glossary seems to have been the starting-point for the Vulgar Tongue reproduced here.