1894 Brewer’s / H / Hypochondria
(Greek, hypo chondros, under the cartilage)—i.e. the spaces on each side of the epigastric region, supposed to be the seat of melancholy as a disease.
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Entry taken from Dictionary of Phrase and Fable, edited by the Rev. E. Cobham Brewer, LL.D. and revised in 1895.