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Spleen

was once believed to be the seat of ill-humour and melancholy The herb spleenwort was supposed to remove these splenic disorders.

 

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Entry taken from Dictionary of Phrase and Fable, edited by the Rev. E. Cobham Brewer, LL.D. and revised in 1895.

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Spiritual Mother
Spiritualism or Spiritism
Spirt or Spurt
Spitalfields (London)
Spite of His Teeth (In)
Spitfire
Spitting for Luck
Spittle or Spital
Spittle Sermons
Splay
Spleen
Splendid Shilling
Splice
Splice the Main Brace
Spoke (verb)
Spoke (noun)
Sponge
Spontaneous Combustion
Spoon
Spoon (A)
Spooning