Guise, Charles, Cardinal of Lorraine, Duke of, son of the succeeding, and considered the ablest of the Guise family; was archbishop of Rheims in 1538, and cardinal of Lorraine in 1547; was prominent at the Council of Trent, and in conjunction with his brother fiercely opposed Protestantism (1527‒1574).
Definition taken from The Nuttall Encyclopædia, edited by the Reverend James Wood (1907)
Guise * Guise, Claude of Lorraine