Guise, Claude of Lorraine, first Duke of, fifth son of René II., Duke of Lorraine; distinguished himself in the service of Francis I., who conferred on him the dukedom of Guise; was the grandfather of Mary, Queen of Scots, through his daughter Marie, wife of James V. of Scotland (1496‒1550).
Definition taken from The Nuttall Encyclopædia, edited by the Reverend James Wood (1907)
Guise, Charles, Cardinal of Lorraine, Duke of * Guise, Francis